Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials.
نویسندگان
چکیده
Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (P < 0.001) and participants treated during early infection (P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point.
منابع مشابه
JAIDS Journal of Acquired Immune Deficiency Syndromes Publish Ahead of Print DOI: 10.1097/QAI.0000000000000964 Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials
Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 ACTG studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (p<0.001) and participants treated during early infection (p<0.001). P...
متن کاملEvaluation of relationship between the level of inflammatory cytokines Interleukin-10 and tumor necrosis factor-alpha with virologic response to treatment in patients with HIV
Background: Despite the considerable advances in acquired immunodeficiency syndrome (AIDS) treatment and management, finding the cure for this disease has been hindered by emerging challenges such as virus resistance and treatment failures. The purpose of this study is to compare the cytokine profiles of patients with successful treatment and patients with unsuccessful treatment to gain a bette...
متن کاملEvidence that intermittent structured treatment interruption, but not immunization with ALVAC-HIV vCP1452, promotes host control of HIV replication: the results of AIDS Clinical Trials Group 5068.
BACKGROUND The ability to control human immunodeficiency virus (HIV) replication in vivo in the absence of antiretroviral therapy (ART) is a measure of the efficiency of antiviral immunity. In a study of patients with chronic, ART-suppressed HIV infection, AIDS Clinical Trials Group 5068 investigated the effects of immunization with an exogenous HIV vaccine and pulse exposure to the subject's u...
متن کاملAssessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection
Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated. Materials and...
متن کاملTreatment interruption in HIV-infected patients with virologic failure may lead to a shift from a drug- resistant to a predominant wild-type plasma viral population
Treatment interruption in HIV-infected patients with virologic failure may lead to a shift from a drugresistant to a predominant wild-type plasma viral population even in individuals with extensive exposure to antiretroviral drugs and multiple virologic failures. Multiple clone sequencing has shown that, after three months of treatment interruption, the proportion of variants harbouring primary...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of acquired immune deficiency syndromes
دوره 72 3 شماره
صفحات -
تاریخ انتشار 2016